Tetracycline represents the class of bacteriostatic antibiotic drugs (tetracyclines) demonstrating considerable effectiveness in eliminating gram-positive
and gram-negative bacteria. The medication is primarily prescribed for the treatment of various urinary infections, acne, gonorrhea chlamydia,and so on.
The drug is approved in the US for regular use; available by prescription only at brick and mortar drugstores.
Tetracyclines class was discovered in the search for microorganisms producing antibiotics in soil samples taken in military parts of the world the first
drug of this group,chlortetracycline appeared in 1948 tetracyclines were active against a number of gram-positive and gram-negative bacteria and chlamydia.
The preparation class has quickly gained popularity as a broad-spectrum antibiotic, and after the relevant studies it has been approved by FDA (a number of
registries starting from 1953 to 1988 has been made).
Tetracycline demonstrates the highest effectiveness when taken an hour before or 2 hours after food intakes. In case of stomach upset, consult your
treating doctor to check whether reception with foods should be continued.
The preparation is recommended to be taken with plenty of water (1 glass). Plan your reception schedule carefully and avoid taking the drug at bedtime to
press for better efficiency it is recommended not to move within 10 minutes after an intake.
The preparation’s effect could be slowed down with the simultaneous consumption of magnesium, aluminum and calcium-rich products do not take such products
at least 2 hours before or after the reception of tetracycline.
Tetracycline targets the process of bacteria reproduction. Typically, it is appointed to combat such infections as Haemophilus influenzae, Salmonella, E.
coli, Shigella, Enterobacter and Brucella. Tetracycline is also prescribed to treat a number of serious diseases, such as cholera, and anthrax (as a part
of an integrated complex of treatment).
At the same time the drug produces antibiotic resistant effect on such bacteria as Pseudomonas aeruginosa, Proteus, Bacteroides, Streptococcus group A
(beta-hemolytic). The drug’s mechanism of action lies in dissociation of the synthesis of protein molecules of bacteria.
Penetrating into the microorganisms, tetracycline promotes disruption of the ribosome complex between special internal fragments of cells, in which the
production of protein molecules with the carrier of the genetic materials.
Ultimately, the bacterium are prevented from producing proteins for their own use, which leads to disruption of the majority of the vital reproduction
Administered orally (in a tablet form), 75% of the applied dose is absorbed by the body. Importantly, the absorption of the antibiotic in the digestive
tract mucosa is decreased with food intakes (in particular when consuming fermented milk products).
As a rule, the desired therapeutic concentration occurs within the first two or three days after the start of treatment.
Dosage and administration
The preparation is manufactured in film-coated tablets in 100 or 250g dose. Apart from the diseases indicated above it can also be prescribed to treat
pneumonia, the genitourinary system, skin infections, conjunctivitis and acne, chlamydia, and other diseases.
Depending on the condition, the drug is prescribed at 250-500 mg dosage every 6 hours in adults. The maximum daily dose for adults should not exceed 4g;
the dosage may be adjusted depending on the treatment progress.