Nexium is an antiulcer agent representing pump inhibitors group. The medication is based on esomeprazole, it’s scope of action is aimed at HCl secretion
reduction by the means of specific inhibition of proton pump in the parietal cells.
Thus, the drug demonstrates decent results in eliminating the symptoms of gastroesophageal reflux diseases, as well as other conditions associated with
high levels of stomach acid. However, the preparation should not be considered as a mean of immediate action.
The preparation is available by prescription only in the United States (physical pharmacies), it has been approved by the FDA for commercial sales for the
first time in 2001; since then a series of updates to the registry has been added, including an enhanced formulation in 2015.
Indications and dosage
The preparation is prescribed as monotherapy or as a part of complex treatment of:
Reflux esophagitis (as symptomatic therapy and anti-treatment, as well as the etiological treatment of peptic forms reflux gastritis)
Helicobacter pylori - in the complex treatment with antibacterial drugs for stomach ulcers and duodenal ulcers
The drug may also be used in preventive treatment of peptic ulcers in cases where the cause of ulcers is the current NSAIDs medications course.
Nexium is designed for perioral use only: the tablets should be swallowed without chewing and a sufficient amount of water (1 glass). If for some reason
swallowing function is violated a pill can be placed in 100 ml of non-carbonated water and taken immediately once the pill is dissolved (it may take up to
In this case, once you consume the liquid, take 1 glass of water (the same amount). Do not use any other liquids except of water in order not to damage the
The active ingredient is unstable in an acidic environment, so the drug inside capsules is covered with an extra layer which protects it from the
aggressive gastric juice.
Treatment of reflux oesophagitis
The effective treatment requires taking 40 mg of preparation per day during 4 weeks. The treatment course may be prolonged to 4 more weeks in case of
insufficient progress. Indicated as a preventive treatment measure the drug should be taken at 20 mg dosage daily.
To press for relief of reflux esophagitis symptoms it is recommended to take 20 mg per day during 4 weeks - clarifying the diagnosis with analyses and
tests may be required.
The drug can also be used as an ‘on demand’ remedy in case of unexpected reflux attacks. However, using Nexium is not recommended as a preventive therapy
for those individuals using NSAID drugs.
In the complex treatment of gastric and duodenal ulcers provoked by Helicobacter pylori infection, or as a part of preventive treatment, you should take 20
mg of Nexium in combination with amoxicillin (1,000 mg) and clarithromycin (500 mg), twice a day during 1 week.
Those taking undergoing long-term NSAID treatment are typically appointed 20 mg of preparation once a day. On average the treatment course of peptic ulcers
provoked by NSAIDs varies from 4 to 8 weeks.
The syndrome Zollinger-Ellison requires taking 40mg of Nexium twice a day. The treatment duration and the dosage are selected individually depending on the
clinical situation; however, the maximum tolerated dose for patients with this syndrome must not exceed 160mg of drug per day.
The preparation must be taken with caution in clinical pictures with liver failure: in such cases the maximum safe dose of the medication equals 20 mg/day.
No dosage adjustment is needed in the elderly and patients suffering from renal insufficiency, however severe renal impairment implies selection of dosage
by the specialist.