A range of drugs exhibiting a diuretic effect are referred to as diuretics. The strongest modifications of these preparations are loop diuretics. Lasix is
a decent representative of loop diuretic medications. Its mechanism of action consists in the blockade of reabsorption of sodium and chloride level in the
renal tubules loop.
These changes increase the osmotic pressure of the liquid in them - filtered by the kidneys it cannot be sucked back. As a result, the liquid with these
electrolytes is removed. Such a strong diuretic effect is the basis of the side effects - a vital loss of potassium and magnesium.
The single active ingredient of Lasix is furosemide. This drug acts of its branded counterparts and has a high degree of purity, a relatively short list of
adverse reactions and contraindications. Another of its advantages is the presence of different dosage forms, it can be used in critical situations.
Lasix produces a well-pronounced diuretic and moderate hypotensive action (lowering blood pressure). The diuretic effect of the drug is implemented through
blocking the reabsorption of sodium and chlorine.
Furosemide gets into the renal tubule, in particular to its part of the loop, which is called a Hegel loop and blocks reabsorption of the aforementioned
substances. Increased allocation of sodium ions leads to increased excretion of fluid, potassium, calcium and magnesium.
A hypotensive effect of Lasix occurs by increasing the separation of sodium chloride (salt) and preventing narrowing of vessels due to a decrease in blood
Hypotensive action is achieved more effectively by intravenous administration. Lasix sufficiently rapidly decreases blood pressure, and the pressure in the
left ventricle and the pulmonary artery, a large vein extends and thus the preload of the heart is reduced.
When administered intravenously, the pressure is reduced in 5-10 minutes, in the case of Lasix tablets pressure returns to normal within 7 hours and stored
within the normal 2-3 hours.
Dosage and administration regimen
The medication is designed for oral use and should be taken before meals without chewing and a small amount of liquid (? of a glass).
The dosage is selected individually by the physician basing on clinical indications. The treatment course is recommended to be started with the lowest dose
that achieve the desired effect. For adults, the maximum recommended daily dose should not exceed 1,500 mg, while in children the dosage is calculated
basing on 2mg per 1kg of weight (but no more than 40 mg). Individual clinically effective dose is selected taking into account the diuretic response.
If the preparation is appointed for edema treatment on the background of chronic heart failure - the initial daily dose ranges from 20 to 80 mg taken in
2-3 hours; in chronic renal insufficiency - the daily dose is 40-80 mg divided in 2 intakes (taking into account a possible loss of fluid at the beginning
of treatment, the dose selection is performed with a gradual increase to avoid sudden loss of fluid), the maintenance dose in hemodialysis ranges from 250
to 1500 mg per day.
The preparation is also prescribed in liver diseases treatment - due to ineffectiveness of aldosterone in monotherapy, 20-80 mg of Lasix per day is
appointed (the treatment must include regular monitoring of fluid loss). The dosage may be adjusted basing on individual parameters - consult your doctor
before initiating the treatment and do not do self treatment to avoid complicated adverse reactions.