Inderal is an propranolol-based medication that blocks beta-adrenoceptors, thus protects the heart from excessive adrenergic stimulation. This action is
applied in clinical practice for the treatment of cardiomyopathies, angina and pheochromocytoma.
The beneficial effects associated with bradycardia treatment is preventing an increase in cardiac output during exercise and a decrease in oxygen uptake in
The preparation in tablet form was approved for use in 1973, since then a series of updates was added to the registry (including new formulations and new
manufacturers; in the US the drug is produced by Pierre Fabre, the 3rd largest French pharmaceutical manufacturer).
Inderal is widely applied in the treatment of various forms of arrhythmias, including those associated with intoxication foxglove, with ventricular
arrhythmia, paroxysmal tachycardia; the medication is also used in combination with digitalis in patients with chronic atrial fibrillation.
The therapeutic action of Inderal is also taken advantage of in a variety of conditions where an increased load on the heart during rest takes place, as
well as in sinus tachycardia, cardiac activity disorders of functional nature. In anesthesiology and resuscitation the preparation is used for arrhythmia
treatment during anesthesia and post-surgery period.
A decrease in blood pressure is observed after administration of propranolol within several days (occasionally weeks).
Despite the possible side effects (such as an increase in cholesterol and sugar levels in the blood), propranolol is a proven medication for effective
treatment of hypertension. For example, it’s positive effect in the prevention of complications of hypertension and a reduction of patient mortality have
been clinically confirmed.
Propranolol (by itself, without any other additional drug for hypertension) at doses of 120-160 mg per day can provide blood pressure normalization in
roughly 30% of patients, while in another 30% significant drop in blood pressure is achieved and clinical improvement occurs.
Even the first dose of propranolol - 40 mg orally - causes a slowing of heart rate, which is clearly trapped between 1 and 2 hours after taking the drug.
Then, the heart rate gradually increases to the original value.
If the patient regularly takes Inderal (2 times a day), the heart rate becomes stable. By the 10th day of treatment at a dose of> 120 mg daily heart
rate is 18% at rest and 23% during physical exercise is less original.
The preparation is designed for oral administration and on average appointed at 0.02g dosage 4 times a day. Angina medication is taken orally by 0.02 -
0.04 g 4 times a day. When applied in treatment of pheochromocytoma the drug is usually prescribed at a dosage of 0.06g per day for 3 days before the
scheduled surgery; as for the long term treatment of - 0.01g is appointed 3 times a day. At the same time in this case, Inderal must be taken with
alpha-blockers (Phentolamine) to eliminate the risk of hypertension.
In the treatment of various forms of arrhythmias Inderal is administered in a dose of 0.01 - 0.03 g, 3-4 times a day.
Arrhythmias during anesthesia and in the postoperative period demand using the drug intravenously at a dose of 0.001g (1.0ml of a 0.1% solution) for 1
minute, with an interval between administrations of at least 2 minutes. The total dose of Inderal should not exceed 0.005g in intravenous administration.
When taken orally, especially when administered intravenously, Inderal can cause bradycardia and hypotension. In such cases atropine sulfate (1.0 ml of a
0.1% solution) is administered intravenously and beta-receptors, isoproterenol or epinephrine, are introduced. The preparation causes largely
non-significant side-effects, such as nausea, diarrhea, insomnia, fatigue, blurred consciousness.