Buy Glucophage (Metformin) Online

Metabolic syndromes are typically accompanied by obesity, type II diabetes and hypertension - the scourge of the modern society attacking a growing number of residents of highly developed regions. This is where Glucophage comes to the rescue - the preparation reducing the level of glucose in the blood and allowing to press for a reduction in weight.

Composition and dosage forms

The drug comes in tablet form of a round shape, white color, packaged in blisters of 10, 15 and 20 tablets. The main active ingredient of the drug is metformin hydrochloride.

Tablets are manufactured in three variants, each containing 500 mg, 850 mg and 1000 mg of active ingredient per tablet. Besides the main active ingredient in each tablet contains inactive ingredients: magnesium stearate and povidone.

Mechanism of action

The drug belongs to the group of biguanides; it is designed to effectively decrease blood sugar levels. Glucophage stands out from similar medications with the absence of hypoglycemia-provoking properties.

Besides, it does not enhance insulin secretion and provides zero impact on blood glucose in healthy humans. Glucophage effect is based on an increase in susceptibility of insulin receptors and acceleration of sugars muscle cells processing.

The medication has a positive impact on fat metabolism: reducing the volumes of bad cholesterol, triglycerides and low-density lipoproteins. Its bioavailability equals at least 50%, therefore, it is rapidly absorbed through the walls of the gastrointestinal tract and the maximum amount of drug in the blood is observed within 2.5 hours after administration.

The active substance does not interact with proteins of blood and spreads very rapidly through the cells of the body. It is almost not processed by the liver and is excreted from the body in urine.

However, there is a possibility of inhibition of the drug in the tissues of patients - the fact should be taken into account in those having a reduced kidney function.

Indications for use

The preparation is prescribed to 18+ years old individuals suffering from diabetes type II, including the cases with severe obesity and insensitivity to insulin; diabetes type II in children and adolescents (10+ years old).

The drug can be appointed as a sole therapeutic preparation, as well as appointed in combination with insulin.

Dosage and administration

The drug is used as the sole drug or in combination with other drugs. For adult patients a primary dose of 500 mg 2-3 times a day with meals or immediately after is appointed.

Given the number of individual measurements of glucose in the blood the dosage can be subsequently increased.

To stabilize the glucose level the daily intake must range from 1,500 to 2,000 mg. To cut down the likelihood of adverse reactions, take Glucophage two or three times a day, but not more than 3000 mg per day divided in up to 3 intakes.

The gradual increase in dosage will result in habituation of the digestive tract and reduce the intensity of side effects. At a daily dosage of 2000 to 3000 mg advisable to take the drug with an active ingredient 1000 mg per tablet.

Wherein the daily dosage should not exceed 3000 mg obtained in three cottages. If the drug to the patient Glucophage previously tried other means for lowering blood glucose levels, should be completely discontinued and taken in such amounts as recommended above.

Application for weight loss in obesity

This drug is used to reduce weight due to activation of fatty acids oxidation, plus it reduces the processing carbohydrates that enter the body with meals.

Glucophage makes the body more susceptible to insulin, thus reducing the production of insulin. It has beneficial effects on the process of weight loss, because thanks to processed insulin calories into body fat. The process has the highest intensity in individuals with abdominal obesity.

Immediately after consuming meals the volume of sugar in the pancreas grows and insulin production starts, which activates the process of converting sugar into fat.

This mechanism is taken into account in the preparation of diets, when losing weight requires giving up foods that sharply increase the level of sugar in blood.

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