A tetracycline antibiotics representative doxycycline has been widely used for decades in medical practice for elimination of infections of various type,
provoked by a wide range of microorganisms. Its intensive use was determined by the lack of alternative antibiotics (the drug was added to the FDA registry
in 1967 for the first time), and a number of favorable pharmacodynamic and pharmacokinetic properties and a wide array of antimicrobial activity.
Thus, the medication has proven effectiveness in the treatment of Gram-positive and Gram-negative, extracellular and intracellular bacteria, Rickettsia,
Borrelia spirochete, Leptospira, actinomycetes, some simple and some other microorganisms. The medication provides nearly complete oral bioavailability,
high concentrations in the tissues; good penetration into cells, longer half-life that allows you to take the medication 1-2 times a day for a double route
of excretion, because dosage adjustments in those suffering from renal insufficiency is not obligatory.
The availability of dosage forms for enteral and parenteral administration and low cost of treatment contributed to the high demand that has partially
preserved till nowadays.
The effectiveness and clinical picture
An extremely wide (and statistically not always rational) use of medication and other tetracyclines has resulted in a significant increase in the level of
resistance to them in a number of common microorganisms.
Furthermore, the clinical practice a range of new beta-lactam and macrolide antibiotics was introduced, so tetracyclines have been almost completely
superseded from such applications as respiratory tract infections, and others. However, currently the interest to tetracyclines and primarily to
doxycycline is gaining momentum again, and not only in the infections in adults, but also in children.
In recent years, doxycycline attracts the attention as an effective mean for the treatment of pneumonia. This is due to several reasons: firstly, the
increase in the proportion of intracellular pathogens (Mycoplasma and Chlamydia) in the etiological structure of pneumonia; secondly, the spread of
epidemic strains of pneumococci pace; thirdly, partial restoration of the sensitivity to tetracyclines of a number of microorganisms.
At the same time, foreign researchers are emphasizing the fact that high-level resistance to tetracycline of pneumococci can not be extended to
doxycycline, as between these drugs there is no cross-resistance. In the case where sensitivity is defined directly to doxycycline, reveals its high
activity even against moderately resistant strains to penicillin S. pneumoniae.
The advantages of doxycycline to tetracycline are also a great bioavailability, longer half-life and a more favorable profile of adverse reactions.
How to take the medication
Doxycycline has proven itself as a cost-effective and efficient agent that eliminates Chlamydia, the drug is boasting impressive results in long-term
general medical practice.
The efficacy of an average therapeutic dose (100 mg 2 times a day for 7 days) in the vast majority of studies exceeds 90%. The drug is manufactured for
oral use (although injections form is also available) it should be taken after meals with plenty of water to prevent possible irritation of the esophagus.
The daily dose or should be taken once every 24 hours (splitting the dose to 2 intakes is allowed if confirmed by the treating doctor).