Clomid is the preparation used in combinative treatment with other medications to stimulate ovulation. The aim of stimulation is to cause the maturation of
one or more eggs. The main effect of clomiphene lies in increasing the levels of follicle stimulating hormone and luteinizing hormones (LH).
In parallel, it increases pituitary prolactin production, and its concentration in the blood above normal prevents ovulation; therefore, prior to and
during stimulation it is required to control prolactin (PRL) level and, if needed, appoint the prolactin-lowering drugs.
Clomid is designed to be taken from 5th to 9th days of the menstrual cycle; the dosage depends on the analysis on hormones before stimulation (initiating
an analysis is an obligatory of the process). The dose for treating picks must be selected by the specialist.
Stimulation is performed under ultrasound guidance. The first ultrasound is generally carried out a week after the stimulation begins. Further, ultrasound
is conducted every two or three days until the follicles do not grow up to the required size about 20-25mm.
The course of treatment
If Clomid doesn’t produce the desired results, the follicle does not grow, and ovulation does take place within 3 cycles, even with an increase in dosage,
the stimulation techniques should be reviewed to conduct additional screening for previously undiagnosed pathologies.
Importantly, Clomid stimulates ovulation, but does not aim at the implantation of the embryo, the resorption of adhesions, etc. It is important to conduct
a full examination prior to initiating the course to exclude the chance of other factors affecting the results (e.g. tubal infertility and male factor).
Moreover, one of the drug’s adverse reactions is modifying the pH level, which contributes to thickening of the cervical mucus that prevents progress of
That is why during pregnancy Clomid stimulation occurs usually not directly in cycles with clomiphene, but the interval between courses or after several
courses of the drug, so the viscosity and pH are restored. During polycystic ovary syndrome the medication is considered to be one of the most effective
drugs that restore ovulation.
However, when restoring ovulation, clomiphene may slightly increase the viscosity of the cervical mucus. In the majority of cases, this additional step is
not crucial, meaning it doesn’t prevent pregnancy.
Dosage and administration
To stimulate ovulation, Clomid is appointed at a dosage of 50 mg once a day at bedtime, starting from 5th day of the menstrual cycle for 5 days (in the
absence of the cycle - at any time). If no effect (ovulation does not develop within 30 days) the dose is is increased up to 150 mg/day or the course is
prolonged up to 10 days.
In no case do not start a Clomid course without prescription and do not increase the dosage on your own.
First, the dose of the drug depends on whether it will stimulate ovulation or suppress it, and secondly hyperstimulation threatens the formation of cysts
and your chances of pregnancy will be postponed indefinitely. It is also not recommended to initiate more than 6 cycles of ovarian stimulation.
The drug’s effect is preserved for several years, and the supply of eggs in the female body is limited and after ovarian hyperstimulation occurs
hyperactivity, threatening ovarian failure and early menopause. Hyperactivity consciously ovarian stimulation is achieved by the process of IVF and this is
the main side effect of long-awaited pregnancy, continuing for many years.
With proper selection of Clomid dosage during stimulation (IVF does not count) the effects are reduced to a minimum and, as a rule, the second and
subsequent pregnancy occurs without problems, while early menopause is not threatened.