As the stresses caused by psychological factors and physiological issues aggravates, it can lead to violations of the metabolism of neurotransmitters in
the nervous system.
As a result, chemical imbalance is often marked by such symptoms of depression as insomnia or appetite, lack of energy, fatigue, poor concentration of
attention and chronic pain. The drugs-antidepressants restore the normal balance of chemicals that addresses some of these symptoms.
Citalopram, the active ingredient of Celexa, is a powerful antidepressant representing the class of selective serotonin reuptake inhibitors (SSRIs). The
drug is approved by the US FDA for the treatment of depression, as well as other diseases associated with depressive states.
The drug is manufactured by Forest Laborotories; entered the market in the 1999th year since the list of entries in the register of FDA repeatedly updated
in the 2005th year were added to the data to update the formula of the active ingredient.
In accordance with an ongoing efficiency survey among registered Drugs.com users, the medication’s effectiveness score of 7.7 out of 10.
The active substance was created in 1998 by Lundbeck, a large pharmaceutical company headquartered in Denmark. Having received a FDA approval, the
commercial sales have been launched, but in 2003 the patent has expired, which meant the company was no longer the only legal supplier of the drug.
Lundbeck was involved in a pharmaceutical scandal for funding generic companies to delay the manufacture of the drug, as a result, it was imposed to 93ml.
Nevertheless, an updated version of the preparation was released with an updated, more effective formulation - Escitalopram (offered under the brand name
Lexapro in the US), representing a S-enantiomer of racemic citalopram. Forest Labs is the only company in the US empowered to sell the drug.
Dosage and administration
The drug is typically appointed to be taken once a day at bedtime or during the morning hours, consumption of foods doesn’t impact the drug effectiveness.
Moreover, a meal intake having no impact on absorption of the active ingredient, but it is more likely to cause nausea. The fact should be underlined that
nausea is highly likely to occur when 5HT3 receptors absorb serotonin, and this receptor is located in digestive tract.
For the same reason 5HT3 receptors may provoke vomiting (although according to the insert the adverse reaction tends to disappears over the time). Unlike
many similar drugs, Celexa is considered to be a safe, well-tolerated preparation when consumed in therapeutic doses.
Standing out from other reps from the class of drugs, the medication is characterized by linear pharmacokinetics and has a minimal potential as for drug
interactions, which makes it an optimal solution in those suffering from renal, kidney problems, as well as in the elderly.
Discontinuation of the drug should be carried out gradually, a continuous clinical monitoring of withdrawal symptoms is required. Exceeding the maximum
daily dosage of 40mg is not recommended.
The dosage depends on the particular condition and is determined by the doctor; the average initial dose is 20 mg per day; If necessary, a gradual increase
in dosage may be assigned.
To determine the response of patients with depression to citalopram, may be carried out testing gene GRIK4. Do not initiate self-treatment - a wrong dosage
may lead to disastrous consequences and cause acute forms of adverse reactions.