The pharmacological action of amoxicillin is utilized in various complexes of treatment. This antibiotic of wide range is referred to the semi-synthetic
penicillins class (a derivative of 6-aminopenicillanic acid). Its bactericidal effect lies in active gram-positive cocci and rods elimination.
The drug demonstrates considerable efficiency in eliminating strains of microorganisms that produce beta-lactamase. An acidic drug, it is designed for
perioral intake - the most effective type of administration.
The drug is characterized by an extremely effective absorption carried out in gastrointestinal tract after intake. The maximum drug concentration
determined in plasma is achieved in 1-1.5 and equal to 7-8 mg/ml.
The high concentration of the drug is built in the lungs, kidneys, urine, mucous membranes of the respiratory tract, bile, pleural and peritoneal fluid.
The half-life of a healthy patient without any signs of renal function abnormalities takes no longer than 2 hours.
Up to 60% of the dose is excreted in the urine within 6 hours (the structure is mostly unchanged).
Therapeutic effect of amoxicillin is characterized by molecular structure which differs from the ampicillin in the molecule a hydroxyl group of
This molecular change increases the rate of absorption of antibiotics, due to which there is less destruction of the ?-lactam ring, while the creation of
high concentrations in the blood takes less time.
Indications for use
Antibiotic therapy with amoxicillin is capable of relieving the symptoms of sinusitis in a week. This applies even to the most complicated forms of
However, it should be underlined that if pus is accumulated in the sinuses, the effect of the drug may be weakened. Furthermore, swelling of the nasal
cavity unwithdrawn may also cause a slight decrease in the effectiveness of an antibiotic.
Today, doctors have a large selection of treatment options for similar to sinusitis diseases: amoxicillin is used in treatment for long periods of time
with noteworthy success, while its medicinal properties have been repeatedly tested and appreciated by patients.
Treatment of sinusitis with amoxicillin is highly dependent on the level of clearness from the rest adverse symptoms of the disease. Therefore, it is
recommended to use a vasoconstrictor drops and sprays, which are composed of antibiotics. However, any signs of colds should be fully cured. In addition,
prior to treatment of sinusitis, make sure that the patient is not having high temperature.
The duration of sinusitis treatment with amoxicillin is equal to 5-12 days depending on the severity of the disease. At the same time, throughout the
course of therapy, the patient must give preference to a healthy lifestyle and plenty of rest.
Dosing and Administration
Amoxicillin tablets are designed for oral administration. Foods consumption does not affect the absorption of the drug from the gastrointestinal tract, so
the patient can take it as before eating as well as after having a meal.
The usual dosage of amoxicillin for adults and children over 12 years (with 40+ kg weight) is 500 mg 3 times a day. However, the dose is determined by the
treating doctor individually depending on the particular case.
If necessary (in case of a severe disease), the dosage can be increased to 750-1000 mg three times a day, or even more. The maximum tolerable daily intake
for adults equals 6g.
In some diseases, a non-standard dosage of amoxicillin is applied. For example, in acute gonorrhea men are appointed to take 3 grams of the drug, while
women are prescribed to take a doubled dose twice a day.
In case of typhoid fever a high dosage of medication is administered: 1.5-2 grams 3 times a day. The patients suffering from leptospirosis are prescribed
500-750 mg of the preparation 4 times per day.
After the disappearance of the external signs of the disease amoxicillin course should be continued for 2-3 days, in order to avoid recurrence of the
infection. The average course of treatment is equals 5 - 12 days.