Acyclovir, the preparation based on the active substance of the same name, is appointed by physicians as an antiviral agent of broad scope of action. Apart
from antiviral action the drug provides a pronounced immunostimulating effect.
Acyclovir is prescribed in type I and II herpes treatment (including its genital form). The medication is also appointed in treatment of mononucleosis,
cytomegalovirus, varicella, herpetic keratitis and localized zoster.
Acyclovir enters the infected cells and blocks their reproduction. On the background of weakened immunity Acyclovir action accelerates the healing of
wounds and reduces the acuteness and duration of pain. The drug is oftentimes considered as preventive measure in immunodeficiency.
In the event of frequent relapses means it is addictive and over time the body loses sensitivity to the drug. Acyclovir is manufactured by various
pharmaceutical enterprises, and the dosage per pill ranges from 200 to 800mg.
The drug’s first record at FDA approved medicines registry dates back to 1982, and since then the formulation has undergone 4 updates.
Indications for use
The tablet form of the drug is taken advantage of in treatment of the skin and mucous membranes infections, herpes simplex virus. As a preventive measures
the drug is used in herpes prophylaxis in individuals people with a normally functioning and weakened immune system, as well as infections caused by
varicella zoster virus.
With a perioral intake approximately 20% of the active substance is absorbed by the body, the remaining concentration is excreted in an unchanged form.
The preparation enters the bloodstream and gets delivered throughout the body, following a partial decomposition in the liver and excretion with the urine
(largely as metabolic product, in the unchanged form).
Acyclovir is capable of overcoming the blood-brain barrier and entering the brain and spinal cord, as well as penetrate breast milk (therefore, the
reasonability of the treatment course must be evaluated by the treating doctor during breastfeeding period).
As soon as the drug penetrates the tissue, the process of conversion of acyclovir into an active substance promoted by specific enzymes, triggering the
virus, takes place. Activated, the active substance a selective penetration of virus-infected cells follows, the preparation modifies the virus DNA and
therefore makes their development and reproduction impossible.
How to use
The drug is designed for oral use. To get eliminate herpes an average dosage of 200mg of preparation 5 times throughout the day is appointed; the treatment
course lasts for up to 10 days. In those patients suffering from severely immunocompromised or malabsorption of gastrointestinal tract the dose should be
In case of prevention of herpes recurrence 200 mg of preparation every 6 hours is appointed. As an option, the schedule can be changed to 400 mg every 12
hours, following a further reduction to 200 mg every 8-12 hours. The treatment course is recommended to be initiated every 6 - 12 months with clinical
For prevention of herpes infection in individuals with a weakened immune system: a 200 mg dose every 6 hours is appointed; in significantly
immunocompromised cases or gastrointestinal malabsorption the amount of active ingredient should be increased.
Self treatment is not recommended to avoid undesired adverse reactions. Take the medication with plenty of water at the same time of the day to maximize
the effect of the drug.